Olufisayo Idowu FAMUYIWA2024-07-092024-07-092023-12Kate TurabianPh.Dhttps://repository.lcu.edu.ng/handle/123456789/636Sars-CoV-2 vaccines have proven effective against COVID-19 infection, but their probable adverse effects, especially on renal and thyroid health, remain a cause for concern in some populations. The overall safety and efficacy of currently available Sars-CoV-2 vaccines have been reported, while few studies have documented post-vaccination complications in the kidney and thyroid. There is currently paucity of such complications in our environment. This study assessed the effects of SARS-CoV-2 vaccination on renal and thyroid functions of apparently healthy individuals in Ibadan, Oyo State. It was a cross sectional study carried out following the Oyo State Ethical Board’ approval. The study population comprised eighty-two SARS-CoV-2 vaccinated and eighty-six unvaccinated apparently healthy male, and female individuals, ages 18 to 65 years. A structured questionnaire was used to obtain the sociodemographic history of the participants. Ten milliliters of blood samples were obtained for the determination of the serum levels of thyroid stimulating hormone, free tri iodothyronine and thyroxine, urea, creatinine, C-reactive protein (CRP), glycated hemoglobin, and SARS-CoV-2 antibodies using standard procedures. The data obtained were statistically analyzed, and the results showed that mean levels of the CRP, glycated hemoglobin, kidney, and thyroid function markers in the vaccinated and unvaccinated groups were not significantly (p > 0.05) different, and were within the reference ranges. The prevalence of thyroid and renal dysfunction showed that 3.6 % (3) of the vaccinated individuals had slightly elevated CRP (1.3 %), FF4 (1.3 %), and TSH (1.3 %). These values were not statistically significant when compared with the unvaccinated group. The estimated levels of thyroid and renal markers six months post Sars-CoV-2 vaccination in this study were within the reference values, and thus, apparently substantiate the safety of the currently available Sars-CoV-2 vaccines in Oyo State, Nigeria. However, the slightly elevated levels of some of these markers in 3.6 % of the population studied cannot be ignored. It is therefore safe to suggest that a medical follow up beyond six months of vaccination should be encouraged. Keywords: SARS-CoV-2; COVID-19; thyroid; kidney; vaccination; C-reactive protein Word count: 300enSARS-CoV-2COVID-19thyroidkidneyvaccinationC-reactive proteinThesis