Temitope David OGUNLEYE2024-07-312024-07-312023-12Kate TurabianPh.Dhttps://repository.lcu.edu.ng/handle/123456789/710This study assessed the post-pandemic renal and thyroid health of SARS-CoV-2-exposed individuals in Ibadan, Nigeria. Corona Virus Disease of 2019 (COVID-19) infection is caused by a novel coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The main manifestation is an acute respiratory illness with interstitial and alveolar pneumonia; however, the possibility of the virus invading other organs cannot be disregarded. Organs, such as the kidney and thyroid glands have been discovered to express the SARS-CoV-2 receptor known as the angiotensin-converting enzyme 2 (ACE2), implying that they are target tissues. Presently, information is scarce on the impact of SARS-CoV-2 viral infection on renal and thyroid functions after the pandemic. Hence this study provides data for the post-pandemic thyroid and renal status of SARS-CoV-2 exposed individuals. This is a cross-sectional study, involving random venous blood samples collection from subjects at different local governments in Ibadan, Oyo state. The socio-demographic information was obtained from 165 subjects comprising 85 unexposed samples; those who tested negative for SARS-CoV-2 virus, who also tested negative for SARS-CoV-2 antibody, and 80 exposed who tested positive for SARS-CoV-2 virus and equally tested positive to SARS-CoV-2 antibody. Inflammatory marker (CRP), renal markers (Cystatin C, Urea, Creatinine, electrolytes; Na +, K +, Cl-, HCO3-), and markers of thyroid function (FT3, FT4, TSH) of the two groups were compared using independent sample T-test. There were no significant differences (p > 0.05) in the Mean ± SD of the inflammatory marker, renal markers, and thyroid function markers of the unexposed samples and exposed samples. This suggests that individuals exposed to SARS-CoV-2 during the pandemic fully recovered. Further studies should be done to determine the post-pandemic effects of viral infection on other vital organs that express the SARS-CoV-2 receptor. Keywords: SARS-CoV-2, Cystatin C, Assessment of the Post-Pandemic, Renal and Thyroid, Health of Sars-CoV-2, Exposed Individuals in Ibadan, Nigeria Word Count: 293enSARS-CoV-2Cystatin CAssessment of the Post-PandemicRenal and ThyroidHealth of Sars-CoV-2Exposed Individuals in IbadanNigeriaThesis