Elizabeth Oluwatoyin AKIN-ODANYE2025-06-112025-06-112024-12Kate TurabiaM.Schttps://repository.lcu.edu.ng/handle/123456789/899This study explored the influence of personality traits, resilience and perceived stigma on cancer patients’ quality of life (QoL) guided by the Contextual Model of Health Related Quality of Life (CM-HRQoL). The study adopted a descriptive quantitative cross-sectional design using survey method. Purposive sampling technique was used to recruit 144 cancer patients from the Radiation Oncology Clinic, University College Hospital Ibadan. Respondents’ ages ranged from 18 to 89 with a mean of 52.64 and standard deviation of 15.20. Sample size was determined using Krejcie and Morgan table. Data was collected using reliable and valid measures of QoL, personality traits (conscientiousness, agreeableness, neuroticism, openness to experience, and extroversion), resilience and perceived stigma. Three hypotheses were tested using regression analysis and ANOVA. Personality traits had significant joint predictive influence on QoL explaining 40.00% of the variance in QoL (F(5,138) =18.66, P<0.01; R 2 = 0.40). However, only neuroticism (β = .56, t = 8.07, P<0.01), conscientiousness (β = -.21, t = -2.74, P<0.05) and extroversion (β = -.17, t = -2.43, P<0.05) had significant independent influence on QoL while openness to experience (β = .07, t = .97, P>0.05) and agreeableness (β = .09, t = 1.22, P>0.05) did not. Furthermore, resilience (F(1,140) = 11.96, P<0.01), perceived stigma (F(1,140) = 47.52, P<0.01) and cancer type (F(1,136) = 2.97, P<0.05) had significant main effect on QoL, but there was no significant interaction effect between resilience and perceived stigma on QoL (F(1,140) = .04, P>0.05) as well as between resilience and cancer type on QoL (F(1,136) = .47, P>0.05). The study concluded that better QoL is associated with h i g h e r conscientiousness, extroversion and resilience while worse QoL is associated with higher neuroticism and perceived stigma. It was therefore recommended that these variables should be considered when designing interventions to improve cancer patients’ QoL. Keywords: Cancer Patients, Personality traits, Resilience, Perceived Stigma, Quality of life. Word Count: 297enCancer PatientsPersonality traitsResiliencePerceived StigmaQuality of life.Thesis