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- Inaugural lectures by Professors from different Faculties of Lead City University
Recent Submissions
Effects of Micronutrient Supplementation on Patients with Drug-Sensitive Mycobacterium tuberculosis and Genetic Identification of Multi-Drug- Resistant Strains in Ibadan, Nigeria
(Lead City University, Ibadan, 2024-12) Ekundayo Joseph OWOLABI
Drug-resistant tuberculosis has been implicated in about 13% of all antimicrobial resistance deaths all over the world. Limited studies have been able to report the genomic characterisation of the multi-drug resistant (MDR) strain of M. tuberculosis in Nigeria. Undernutrition is a factor implicated as a cause of immune deficiency in most tuberculosis (TB) patients. The effects of micronutrients as adjuvant therapy in the management of tuberculosis have not been well documented in Nigerian TB patients. This study was designed to investigate the possible influence of zinc, selenium and iron supplements on TB patients undergoing intensive anti-TB therapy and also compare the genomic sequence of MDR TB with drug-sensitive Tubercle bacilli. One hundred newly diagnosed patients with drug-sensitive (DS) M. tuberculosis patients
were recruited after the screening of sputum at the molecular level. Ten MDR positive M. tuberculosis and twenty-five normal individuals (controls) who were mycobacterium negative screened by Genxpert at Jericho Chest Government Hospital, Ibadan also participated in this study. The 100 drug-sensitive positive M. tuberculosis patients were classified into 4; groups 1-3 had anti-TB drugs plus iron, selenium or zinc supplementation, while group 4 had anti-TB drugs only. Baseline and 2 months post-treatment weights were measured, and blood samples were collected. MDR TB and DS sputum samples were used for the culture and genomic characterisation of M. tuberculosis. Results showed that baseline weights were significantly (p<0.05) lower when compared with the controls. After two months, patients on iron and selenium supplementation showed a significant increase in weight compared to the baseline values. Baseline levels of ferritin, IgG, C3, CRP, and D-dimer were significantly (p<0.05)
higher, while levels of Hb, iron, selenium, zinc, and albumin were significantly (p<0.05) lower compared with controls. However, patients on Fe, Se and Zn supplementation had significantly higher levels after 2 months of treatment. This study identified the rpoB gene and KatG gene in MDR strains of M. tuberculosis. The phylogenetic analysis showed that some drug-sensitive and drug-resistant positive TB had clusters of both M. tuberculosis and M. bovis. It could be concluded that M. bovis shared similar clusters with M. tuberculosis probably due to a gene mutation that could accounts for drug resistance in MDR-TB. It may be necessary to consistently conduct a phylogenetic analysis of samples to identify which samples have a cluster common to MTB and M. bovis. This could help in reducing MDR-TB infection and possibly decrease the number of deaths. Consumption of micronutrients seems to have have effects on D-dimer, C- v reactive protein, complement factor-3, iron, ferritin and albumin, possibly by enhancing metabolic activities, reducing inflammation, preventing iron deficiency anaemia, reducing intravascular coagulation, and modulating immune response of patients to infection.
Keywords: DNA sequencing, Immune system, Micronutrients, Multi-drug resistance, Tuberculosis-infection.
Word Count: 429
Training Assessment, Information Communication Technology Use and Senior Secondary School Principals Job Performance in Lagos State
(Lead City University, Ibadan, 2024-12) Olabanke Aduke YUSUF
In recent years, there seems to be a noticeable concern regarding the job performance of principals in public senior secondary schools in Lagos State. This is evident in poor
management practices, reduced parental satisfaction, decreased teacher morale, poor job satisfaction, negative reputation and perception and so on. Factors contributing to these challenges could be inadequate training of school principals, high administrative burden, burnout and stress, among others. Previous studies have highlighted numerous factors causing the aforesaid problems in other states, but work has not been done specifically, addressing this issue within the context of public senior secondary schools in Lagos State. To fill this gap, this study aims to investigate the influence of training assessment and information communication technology use on senior secondary school principals job performance in Lagos State. A descriptive research design of the survey type was used to guide the study. The population consists of all 323 principals in public senior secondary schools in Lagos State. An Intact sampling technique and a self-developed questionnaire (PJPQ) for principals was utilised. The findings revealed that the level of job performance of senior secondary school principals in Lagos State is high( x̄=3.19); the level of training assessment of senior secondary school principals in Lagos State is high( x̄=3.07); the level of ICT use among principals in senior secondary school in Lagos State is high( x̄=3.07); the combined influence of training assessment and ICT use has a significant influence on job performance of senior secondary school principals in Lagos State(Adj. R 2 =0.987) and
(F(2,275)=10271.187; p< 0.05); technology integration demonstrates the strongest influence on principals job performance (β=0.640, t=15.919, p< 0.05). Based on these findings, it was recommended among others that schools should invest in ongoing ICT training that keeps principals abreast of emerging technologies and their applications in education.
Keywords: Training Assessment, Information and Communication Use, Job Performance
Word Count: 298
Emerging Technology Awareness, Data Literacy Skills, Institutional Support and Digital Records’ Management Practices among Librarians in Universities in Southwest Nigeria
(Lead City University, Ibadan, 2024-12) Fehintoluwa Elizabeth OMOSEBI
Digital records are becoming more pervasive in library and information centers which means that the traditional records management practices may no longer be effective. Taking up digital records management practices however requires some skills and strategies which may not be available to all. This study therefore examines the influence
of emerging technology awareness, data literacy skills, and institutional support on digital records’ management practices among librarians in universities in southwest Nigeria. The study adopted a mixed method research approach, combining both quantitative and qualitative methods. The research instrument consisted of a structured questionnaire, adapted from previous. The questionnaire was administered on 378 librarians from universities across south-west Nigeria out of which 272 were returned. Data analysis was done through the use of descriptive and inferential statistics. The results showed a high engagement in digital record management practices among the librarians (Mean = 3.31). The result also showed a high level of awareness of emerging technologies (Mean = 3.42), data literacy skills (Mean = 3.41), and institutional support (Mean = 3.04). Furthermore, the test of hypotheses revealed that, while emerging technology awareness (Adj R2 = .220; P >0.05) and data literacy skills (Adj R
2 = .285; P >0.05) have significant influence on digital records management among the respondent, institutional support (Adj R 2 = .008; P <0.05) does not significantly influence digital records management practices. The study concluded that the high level of awareness and data literacy skills among librarians is an encouraging sign that should be boosted through adequate capacity development and institutional support which currently is not at the expected level. It was therefore recommended that universities libraries in Southwest Nigeria should invest in regular and comprehensive training programs focused on digital record management practices.
Keywords: Data literacy, Digital Records, Emerging Technologies, Institutional Support, Library Technologies, Records Management
Word Count: 285
Work Environment, Reward System and Job Satisfaction of Secretaries in Public Polytechnics, Oyo State, Nigeria
(Lead City University, Ibadan, 2024-12) Omolayo Comfort KAYEWUMI
Secretaries are pivotal to the smooth running of organisations and their job satisfaction could offer significant benefits to the organisation. Despite this, few studies have
examined factors determining the job satisfaction of secretaries. In line with this, the study examines the influence of work environment and reward system on job satisfaction of secretaries in public polytechnics, Oyo State Nigeria. The population of the study included two hundred and thirty secretaries (230) across three public-funded universities in Oyo State. The survey research method was adopted with a total enumeration of the sample. The research instrument was a structured questionnaire adapted from theories and previous studies. Data analysis was conducted using descriptive and inferential statistics. The results showed a moderate level of job satisfaction among the respondents. It was also found that, while the work environment is perceived as highly positive, the reward system was rated low by the respondents. In addition, the test of hypothesis revealed that work environment has a significant influence on job satisfaction among the respondents while reward systems have no significant influence. Nevertheless, the combination of work environment and reward system has a significant influence on job satisfaction. The study concluded that while secretaries can compensate cope with less than-ideal reward system, an unconducive physical working environment would lead to job dissatisfaction. It was therefore recommended that management of public polytechnics should review and improve the salary structure and benefits packages. Competitive remuneration, aligned with industry standards, will help increase satisfaction and reduce turnover rates
Keywords: Human Resources, Job Satisfaction, Reward Systems, Work Environment, Organisational Performance.
Word Count: 246
Organizational Culture, Computer Self-efficacy and Administrative Effectiveness of Secretaries in Public Polytechnics, Oyo State, Nigeria
(Lead City University, Ibadan, 2024-12) Oluyemisi Omowumi FASIPE
Organizational culture, computer self-efficacy, and administrative effectiveness are crucial aspects of public polytechnics in Oyo State, Nigeria, that are interrelated and can impact the performance of secretaries; however, these areas have been perceived as major challenges, leading to several administrative inefficiencies. The study, therefore, examined the influence of organizational culture, computer self-efficacy, and administrative effectiveness of secretaries in public polytechnics in Oyo State, Nigeria. The descriptive survey design was adopted, with a sample size of 149 secretaries drawn from public polytechnics in the state. Data were collected using a questionnaire, with reliability tests yielding 0.65 for administrative effectiveness, 0.69 for organizational culture, and 0.72 for computer self- efficacy. Descriptive and inferential statistics were used for data analysis. Utilizing a sample of 149 respondents, findings indicate a moderately high level of administrative effectiveness among secretaries, as reflected by a weighted mean score of 3.254 (x̅= 3.25), with low variability in responses. The prevalent organizational culture in these polytechnics emphasizes Basic Underlying Assumptions (mean = 3.268), (x̅= 3.27), surpassing Artefacts (mean = 3.182) and Espoused Values (mean = 3.098). This highlights a strong focus on core beliefs guiding organizational behavior. Additionally, the secretaries exhibit high computer self-efficacy, with a weighted mean of 3.72 (x̅= 3.72) across mastery experience, social
persuasion, and vicarious learning, suggesting strong confidence in using technology for administrative tasks. Regression analysis demonstrates a significant combined influence of organizational culture (F = 30.071, p < 0.000), and computer self-efficacy (F = 10.015, p < 0.000) on administrative effectiveness, with specific elements of culture, such as Artefacts and Espoused Values, playing key roles. The study concluded that organizational culture and computer self-efficacy significantly influence secretaries' administrative effectiveness in Oyo State polytechnics. Continuous training and promoting a strong organizational culture were recommended to enhance computer self-efficacy and improve administrative outcomes.
Keywords: Administrative effectiveness, Computer self-efficacy, Organizational Culture, Public polytechnics, Oyo State, Secretaries,
Word Count: 300