Department of Public Health

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Department of Public Health

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Browsing Department of Public Health by Subject "Anaplastic Lymphoma Kinase (ALK)"

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    Nutritional Bio-Active Compounds in Annona Muricata (Soursop) and its Potential Role in Promoting Health and Preventing Disease (Cancer)
    (Lead City University, Ibadan, 2024-12) Margaret M. Mosimabale
    Non-communicable diseases (NCDs) such as cancer are leading causes of morbidity and mortality worldwide. Among various therapeutic targets, the Human Anaplastic Lymphoma Kinase (ALK) enzyme plays a crucial role in the development of certain cancers. This study investigates the nutritional bioactive compounds in Annona Muricata (soursop) and their potential in promoting health and preventing cancer. This study was carried out to comprehensively investigate the fruit (flesh), seeds, and skin of Annona muricata by analyzing their proximate composition, characterizing and screening the methanolic extracts of the seed and flesh using Gas Chromatography-Mass Spectrometry (GC-MS), and assessing the antioxidant properties of the extracts through assays including DPPH scavenging, Nitric Oxide (NO) assay, ferric reducing antioxidant power (FRAP) assay, and lipid peroxidation (LPO) assay. Additionally, computational study (in silico) was conducted to assess the inhibitory properties of bioactive compounds in the methanolic extracts against the Human ALK enzyme. Phytochemical screening revealed the presence of alkaloids, tannins, phlobatannins, saponins, phenols, reducing sugars, steroids, cardiac glycosides, terpenoids, and flavonoids in the seed, flesh, and bark of Annona Muricata. Antioxidant assays demonstrated significant total antioxidant capacities, with the bark showing the highest capacity (41.10 mg/100g), followed by the flesh (36.53 mg/100g) and the seed (35.30 mg/100g). The GC-MS analysis identified 134 compounds in the methanolic extracts, and molecular docking studies revealed that several of these compounds exhibit strong binding affinities with the ALK receptor. Notably, Tricyclo[20.8.0.0(7,16)]triacontane, 1(22),7(16)-diepoxy (TTD) exhibited the highest binding affinity at -8.3 kcal/mol, outperforming the standard reference drug Ceritinib (-7.2 kcal/mol). These findings suggest that Annona Muricata contains potent bioactive compounds with significant antioxidant properties and potential inhibitory effects on cancer-related enzymes, highlighting its potential as a functional food in cancer prevention and health promotion. Keywords: Annona Muricata, Anaplastic Lymphoma Kinase (ALK), bio-active compounds, antioxidant, phytochemicals, functional food, soursop, cancer. Word Count: 282