Molecular Characterization of Hepatocyte Nuclear Factor 1 alpha Gene in Diabetic Patients in Lagos State, Nigeria
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Date
2025-12
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Lead City University Ibadan
Abstract
Diabetes mellitus (DM) is one of the most pressing public health challenges globally, characterized by chronic hyperglycemia due to either insulin deficiency or resistance. This study investigates prevalence and molecular characterization of HNF1A gene variants among diabetic patients in Lagos, Nigeria, highlighting non-genetic risk factors such as age, gender, and body mass index (BMI). A cross-sectional study involving 100 participants was conducted, demographics, biochemical analyses, fasting blood glucose, HbA1c, and the presence of specific gene variants using PCR were carried out. 47 of the 100 study participants (47%) were males while 53% were females. Mean age of participants was 46.45 years while 40% of the
participants were aged 51-70 years. Also, 63% of study participants had normal BMI of 24.3 while 37% were obese. The mean values showed significant difference for both age and sex with p < 0.000 and 0.003 respectively. The mean values showed significant difference for age but no
within sex and BMI at 95% confidence level (p < 0.05). The parameters tested for showed no significant difference for age, sex and BMI with respect to the genetic variants at 95% confidence level (p < 0.05). The overall percentage of PCR shows 60% positive and 40% negative. In addition, 51.7% of male are positive and 48.3% are negative, but 65% of female are positive and 35% are negative. The findings revealed a higher prevalence of diabetes among older participants with increased BMI, emphasizing their role as significant risk factors. Notably, the HNF1A gene showed variations, yet no statistically significant association between these variants and diabetes status was found. This suggests HNF1A mutations might influence glycemic control, other factors such as lifestyle and environmental factors may also play roles in diabetes pathogenesis. Therefore, early screening and identifies genetic screening as a potential tool for precise diabetic care.
Keywords: Prevalence, Diabetes Mellitus, Hepatocyte Nuclear Factor 1 alpha, Glycated Hemoglobin, Polymerase Chain Reaction.
Word Count: 298 words
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Keywords
Prevalence, Diabetes Mellitus, Hepatocyte Nuclear Factor 1 alpha, Glycated Hemoglobin, Polymerase Chain Reaction.
Citation
Kate Turabian